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Portret photo Joost Verhaagen

Post-Doctoral Fellow Neuroimmunology

Type
Research
Location
Amsterdam
Description
You will, together with a PhD student, identify targets promoting remyelination in human post mortem MS brain tissue and validate these targets in vitro. In addition, you will be involved in the immunohistochemical analyses of effects of targets tested in animal models for MS. Development of non-invasive viral vectors to deliver the targets to the CNS and evaluation of the effects in animal models, will be done by an additional postdoctoral fellow, PhD student and technician of the Start2Cure team “Regenerative Gene Therapy for MS”.
FTE
38 hours
Period
2 years with additional 2 years


Description

For applying for this vacancy click here

In a joint research program of Verhaagen and Huitinga, funded by the Start2Cure Foundation, we will identify molecular pathways relating to remyelination in a clinically and neuropathologically well-characterized MS autopsy cohort of the Netherlands Brain Bank. We will study tissue of MS brain donors with a high intrinsic capability to remyelinate using gene expression profiling and (high resolution) microscopy. Targets will be validated in vitro using iPSC derived human oligodendrocytes and in vitro in animal models for MS using cutting edge gene therapy technology to deliver therapeutic targets to the CNS. Together with Start2Cure we will push for recovery of brain damage in MS by shortening the path from science to clinical application.

Requested skills:

  • Experience in neuroimmunology, specifically MS-related pathology
  • Experience with gene expression profiling in brain tissue (bulk RNA seq, sc hnRNA seq, in situ RNA seq)
  • Experience with analyses of (human) brain tissue using light-, CLSM- and STED- microscopy
  • You are a team player, proactive, a natural problem solver and enjoy making fast progress

Appreciated skills

  • Experience with data analyses and R

Environment

The Netherlands Institute for Neuroscience is the country’s leading fundamental neuroscience research institute, in the international and progressive city of Amsterdam. It provides a critical mass of scientists (spanning more than 27 nationalities) and neuroscience facilities, in a highly interactive, dynamic, multi-cultural environment, with English as the working language.

Appointment

Appointment will be for 2 years and additional 2 years in case of good performance. The salary is in accordance with the regulations for academic personnel, and will range from €3282,- up to 4.490,- gross per month (excluding 8% holiday and 8,3% end of year allowance) based on a full-time appointment, and depending on expertise and previous experience. The gross monthly salaries are in accordance with the Collective Labour Agreement (CAO) for Dutch Universities. We offer travel expenses, paid parental leave, flexible working hours, 30 days paid leave per year and help by finding a house.

Starting date

As soon as possible

TO APPLY

Applicants are welcomed to submit their application through (and only through, do not use the apply button on this page) the online form here until May 15th, 2022. The online application will include four sections:

  • general information
  • education and research experience
  • research and personal skills
  • CV, motivation letter and recommendation letters.

Evaluation of candidates will begin immediately, and continue until the position is filled.

Additional information

For additional information please contact Prof. Inge Huitinga ([email protected]) or Prof. Joost Verhaagen, ([email protected]).