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Internship: Testing vision of mutated zebrafish

Type
Student Project
Location
Amsterdam
Description
Behavioral testing of zebrafish; electro retinogram measurements; immunocytochemistry; single cell electrophysiology
FTE
1 FTE
Period
17 weeks
Daily support
Dr. L. Klaassen Drs. T. Sjoerdsma


Description

Retinal Signal Processing Group

We study neural processing of visual stimuli by the retina. As an animal model we use zebrafish because these animals are highly visually oriented and can genetically be modified. At present we have mutated zebrafish with defects in retinal processing. These fish are tested in behavioral tasks using optokinetic and optomotor assays. Furthermore, the electrical responses of the eye are evaluated using ERG measurements and the morphology of the retina is studied using morphological techniques. Single cell electrophysiological methods (patch-clamp, intracellular, extracellular, multi-electrode) are used to analyze the properties of single retinal neurons.