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Portret photo Joost Verhaagen

Verhaagen Group

A new mechanism that prevents regeneration

New research shows T cells prevent damaged nerve cells from regenerating due to a reversible, ageing-related mechanism. A new study in mice led by a group of different researchers, including researchers from the Netherlands Institute for Neuroscience, has revealed that this may be due to T cells blocking regenerative signals in nerve cells with age. The findings, published in Science, also provide positive evidence that these T cells can be repressed using targeted drugs called monoclonal antibodies to restore and improve nerve cell regeneration.

Read more about the research here, where Genevieve Timmins writes about the research in an press-release.

 

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Portret photo Joost Verhaagen

Verhaagen Group

This laboratory performs basic and translational research with the aim to advance the field of restorative neuroscience and neurology. We focus on the cellular and molecular mechanisms that underlie degeneration, regeneration and plasticity of the central and peripheral nervous system. A significant portion of research is dedicated to the identification of novel genes and molecular pathways that affect the capacity of the nervous system to regenerate. Genomics, bioinformatics and high-throughput functional screening are key components of our research strategy and gene therapy based on advanced viral vector technology is applied to validate the therapeutic efficacy of molecular targets in clinically relevant animal models of neurodegeneration and repair. The ultimate goal of the Laboratory for Neuroregeneration is to develop novel therapeutic strategies to promote regeneration and plasticity of injured axons.

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