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Ingo Willuhn

Neuroscience Symposium
Willuhn Group

The Neuroscience Symposia are organized weekly by the Netherlands Institute for Neuroscience. The presentations are given by researchers from the institute or by guest speakers. The title and content of the symposium is usually made known in the week prior to the presentation.

The symposium will be held online. A zoom link will be provided by email.

4 pm – Aishwarya Parthasarathy – Neural substrates of inhibitory control in the medial prefrontal cortex.

Several compulsivity disorders like obsessive-compulsive disorder and addiction are associated with impaired inhibitory control of behavior. The inability to inhibit aberrant behaviors is often linked to dysfunctional encoding of expression and suppression of appetitive behavior. Recent work suggests that Prelimbic (PL) and Infralimbic (IL) cortices play dichotomized roles in the expression and suppression of such appetitive behavior, respectively. However, the neural encoding of appetitive behavior in PL and IL are insufficiently understood. To this end, I am investigating how populations of neurons within PL and IL are coordinated and collaboratively establish behavior in a go/no-go task. I will share preliminary results and describe future plans for this project.

4:30 pm – Tara Arab – Electrophysiological correlates of compulsive behavior.

Compulsivity, understood as the performance of repetitive behavior without voluntary control, is a prominent factor in several psychiatric disorders, including obsessive-compulsive disorder (OCD). While evidence suggests that abnormal cortico-striatal interactions may play a role in compulsive behavior, its neurobiological roots are not clear. To improve clinical outcomes for these disorders, it is essential to understand and specifically target abnormal activity of striatal and prefrontal cortical networks. I will discuss our findings from rodent and human in vivo electrophysiological recordings in the cortico-striatal network during compulsive behavior, identifying potential neurological biomarkers of compulsivity.