2 March 2018

Steven A. Kushner

Neuroscience Symposium
Kole Group

The Neuroscience Symposia are organized weekly by the Netherlands Institute for Neuroscience. The presentations are given by researchers from the institute or by guest speakers. The title and content of the symposium is usually made known in the week prior to the presentation.

Guest speaker Maarten Kole

Colloquium room – Netherlands Institute for Neuroscience

4:00 pm – Oligodendrocyte progenitor cell dysfunction in familial schizophrenia
4:45 pm – Discussion and drinks

Previous studies have identified well-replicated structural abnormalities of white matter in schizophrenia, including in first-episode and treatment-naive patients. However, the causality of these changes has been difficult to ascertain. Seemingly unrelated abnormalities of parvalbumin (PV) interneurons in schizophrenia post-mortem neocortex have also been consistently observed, the leading candidate mechanism for disease-related deficits in gamma oscillations. In my talk, I will describe our findings combining family-based rare variant genetic discovery with induced pluripotent stem cell (iPSC) modeling which now suggest that oligodendrocyte progenitor cell dysfunction should be considered as a candidate etiological cell type in schizophrenia. Moreover, I will also discuss our finding that fast-spiking PV interneurons in the neocortex and hippocampus are very frequently myelinated and exhibit a form of activity-dependent myelin plasticity, which might represent an important locus of pathophysiological convergence.