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Tim Czopka

Neuroscience Symposium
Kole Group

The Neuroscience Symposia are organized weekly by the Netherlands Institute for Neuroscience. The presentations are given by researchers from the institute or by guest speakers. The title and content of the symposium is usually made known in the week prior to the presentation.

Guest speaker Kole group.

The symposium will be held online. You will receive a link by email.

4 pm – What is the Role of Oligodendrocytes in the Central Nervous System?

Abstract:
A major challenge for understanding our central nervous system (CNS) is to elucidate the mechanisms by which the myriads of neurons and glial cells that constitute our brain and  spinal cord coordinate and influence each other to form and maintain a functional organ.

Oligodendrocytes and their undifferentiated precursor cells represent an abundant glial population in CNS. It is well established that myelinating oligodendrocytes unsheathe axons, and in doing so regulate transmission speed between nerve cells and ensure long-term axonal health. However, there are many more non-myelinating oligodendrocytes precursors throughout the brain lifelong, than ever differentiate to form new myelin. How this cell population affects nervous system function remains largely unclear.

My group investigates principles of how neurons and oligodendrocytes communicate, how oligodendrocytes integrate information from neurons, and what they do with this information. To do this, we use zebrafish as an in vivo model organism, which are ideally suited for high-resolution microscopy of intercellular communication, cellular genetic and physiological manipulations, as well as behavioral analyses. I will present an overview of the state of current research and our approach to address open questions in the field.