Tommaso PatriarchiNeuroscience Symposium
The Neuroscience Symposia are organized weekly by the Netherlands Institute for Neuroscience. The presentations are given by researchers from the institute or by guest speakers. The title and content of the symposium is usually made known in the week prior to the presentation.
Guest speaker Willuhn group
The symposium will be held online. A zoom link will be provided by email.
4 pm – New tools to reveal the hidden chemistry of the brain.
Measuring the real-time dynamics of neuromodulator release in the brain with subcellular resolution is a long-sought goal in neuroscience, due to the immense implications for basic science and medicine. The past 3 years have brought this goal within reach, with the appearance of a new class of genetically encoded fluorescent sensors for neuromodulators constructed using G-protein-coupled-receptors (GPCR) as their backbone. For example, the dopamine (DA) sensor family dLight1 has proven the ability to track DA release dynamics at a sub second resolution, with sub micromolar affinity and high molecular selectivity. In this talk I will present some of our recent efforts on the development of a new sensor that allows ultrasensitive detection of neuropeptides in vivo. The deployment of novel tools like this are expected to greatly improve our understanding of the complex roles these important neurochemicals have in regulating animal physiology both in health and disease states.