Huitinga Group

The Neuroimmunology group aims to investigate the molecular and cellular factors underlying multiple sclerosis (MS). Special emphasis is put on the role of microglia in the initiation and expansion of MS lesions. The group investigates effects of neurosteroids (sex steroids, glucocorticoids and Vitamin D), complement, CD200 and scavenger receptors on microglia activation and MS lesion development using post mortem MS brain tissue and CSF from more than 200 MS brain donors of the Netherlands Brain Bank and in vivo and in vitro models of demyelination.


Huitinga Group

Inge C. M. Hoogland , Dunja Westhoff , Joo-Yeon Engelen-Lee , Jeroen Melief , Mercedes Valls Seron , Judith H. M. P. Houben-Weerts , I. Huitinga , David J. van Westerloo , Tom van der Poll , Willem A. van Gool , Diederik van de Beek Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coil Frontiers in Cellular Neuroscience 12 (2018) Download

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