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Lohmann Group

Synapse and Network Development

The development of specific synaptic connections between nerve cells is a fundamental step during the maturation of the brain, but its underlying mechanisms are largely unknown. To investigate how neurons establish specific connections, we apply high resolution imaging and electrophysiology in brain slices and in vivo.

Our goal is to identify patterns of neuronal activity, forms of calcium signaling and molecular factors that regulate synapse development. We focus on the local regulation of synapse maturation and its relationship with activity patterns in the entire cell and the emerging network.

 

Publications

Lohmann Group

Juliette E Cheyne, Nawal Zabouri, David Baddeley, Christian Lohmann Spontaneous Activity Patterns Are Altered in the Developing Visual Cortex of the Fmr1 Knockout Mouse Frontiers in Neural Circuits 13 (2019) 57 Download

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