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Lohmann Group

Synapse and Network Development

The development of specific synaptic connections between nerve cells is a fundamental step during the maturation of the brain, but its underlying mechanisms are largely unknown. To investigate how neurons establish specific connections, we apply high resolution imaging and electrophysiology in brain slices and in vivo.

Our goal is to identify patterns of neuronal activity, forms of calcium signaling and molecular factors that regulate synapse development. We focus on the local regulation of synapse maturation and its relationship with activity patterns in the entire cell and the emerging network.

 

Publications

Lohmann Group

Dragos Niculescu , Kristin Michaelsen-Preusse , Ülkü Güner , René van Dorland , Corette J Wierenga , C. Lohmann A BDNF-Mediated Push-Pull Plasticity Mechanism for Synaptic Clustering Cell Reports 24 (2018) 2063-2074 Download

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