Synapse and Network Development
The development of specific synaptic connections between nerve cells is a fundamental step during the maturation of the brain, but its underlying mechanisms are largely unknown. To investigate how neurons establish specific connections, we apply high resolution imaging and electrophysiology in brain slices and in vivo.
Our goal is to identify patterns of neuronal activity, forms of calcium signaling and molecular factors that regulate synapse development. We focus on the local regulation of synapse maturation and its relationship with activity patterns in the entire cell and the emerging network.
Additional information and articles
- ‘Spontaneous brain activity in babies prepares their brains for the rest of their lives’
- Lab Outings
A BDNF-Mediated Push-Pull Plasticity Mechanism for Synaptic Clustering Cell Reports 24 (2018) 2063-2074 Download