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PhD Student in Neuroimmunology

Research group Huitinga
Hours Fulltime
Location Amsterdam
Duration 4 years

Max hours per week: 38 hours
Max salary: € 3.247
Apply until: 1 March 2023

The Neuroimmunology Research (IMM) group, led by Prof Inge Huitinga, studies the molecular and cellular factors underlying the pathology of multiple sclerosis (MS) with a focus on the role of microglia, T- and B-cells and de- and re-myelination and has a vacancy for a PhD student in neuroimmunology.

The project is a collaboration between the IMM group at the NIN and profs. Tanja Kuhlmann and Louisa Klotz at the Depts of Neuropathology and Neurology of the University of Münster. The teams together recently identified in a MS tissue collection of the Netherlands Brain Bank (n = 186) two extreme ends of the disease spectrum, i.e. with either a very rapidly (n = 29) or slowly progressive disease course (n = 33). Neuropathological analysis shows a distinct phenotype of lesions in the rapid disease group characterized by significantly broader MS lesions rims as compared to those in the small rim group. The aim of the project is to analyze the cellular and molecular characteristics of both the broad and small rim lesions in both groups using high resolution spatial transcriptomics and immunohistochemistry using light and STED microscopy. The project is financed by a grant of the National MS Society (USA) and a MOVES grant.

Desired skills:

  • Experience with human brain tissue research including RNA seq analyses and high resolution microscopy
  • Experience or affinity with computational analyses

We are looking for team players with specific interest in CNS with excellent communication skills and ability to work and troubleshoot independently and collaboratively.

The team

The project will be executed in the IMM group at the NIN in close collaboration with the Dept of Neuropathology of the University of Münster (profs. Kuhlmann and Klotz) and the Depts of Neurology and Immunology in ErasmusMC (dr. Smolders).

Salary

The gross monthly salary based on full-time employment varies between € 2.541,- in the first year and € 3.247,- gross per month (salary scale P) in the last year, in accordance with the Collective Labour Agreement for Dutch Universities (CAO NU), excluding 8% holiday allowance and 8.3% end-of-year bonus. We offer travel expenses, paid parental leave, flexible working hours, 30 days paid leave per year and help by finding a house.

Appointment

The position is for a maximum period of 4 years in total. The first appointment is for one year with the option for an extension for the remaining period pending on an evaluation.

Starting date: immediately

Terms of employment

Depending on education and experience the minimum salary is €2541,- and the maximum salary is €3247,- gross per month for a full-time appointment (scale P cao Nederlandse Universiteiten/KNAW). This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP.

The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment).

For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.

Diversity & Inclusion

The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy.

Evaluation of candidates will begin immediately, and continue until the position is filled. To apply, please send an application letter, CV, including two letter of recommendation via the ‘Apply directly’ button.

We will not respond to any supplier enquiries based on this job advertisement.

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