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Portretfoto van Eus van Someren die poseert in het slaaplab.

Van Someren Group

Prestigious grant for pioneering research on insomnia and anxiety

Anxiety disorders and chronic insomnia are the two most common psychiatric conditions. Can’t we improve their arduous treatment?

Unfortunately, there is not enough knowledge about the underlying causes to be able to better treat these conditions. This is now going to change. A team of sleep researchers from the Netherlands Institute for Neuroscience, the Vrije Universiteit Amsterdam and the Amsterdam University Medical Centre will study the disorders not separately from each other, as has been done so far, but together.

“When one sees how often anxiety and insomnia occur together, it is actually strange how separately these disorders have been studied and treated so far”, says ‘Sleep Professor’ Eus van Someren. “There is also a strong overlap in experienced complaints. People feel tense, stressed, ‘hyper’. This is also measurable in the activity of the brain and other organs. Overcoming these unbearable symptoms can be done better if we do not artificially separate day and night.”

Prestigious grant

To achieve better treatment, the European Research Council (ERC) of the European Commission made the exceptional decision to award its most prestigious grant, the ‘ERC Advanced Grant‘ to Van Someren for the second time. His research team has been trying for years to improve treatment of insomnia and to prevent its adverse consequences for mental health. Their discoveries have made the Netherlands the international leader in the field of fundamental research into insomnia.

Together with patients

Via slaapregister.nl, – a Dutch website for recruiting volunteers for sleep research – his team is looking for research participants who, in addition to their poor sleep, also have complaints of anxiety, stress or emotion regulation. Thousands of people can contribute to the research by filling in questionnaires. Hundreds of them can also take measurements of their brain activity before, during and after sleep in the comfort of their own bed. Treatments will also be tried out, including innovative medication. Van Someren expects that people will find it easier to control their anxiety and post-traumatic stress symptoms if they sleep better.

Van Someren: “From my many conversations with patients, psychologists, psychiatrists, somnologists and researchers, I have noticed time and again how difficult it apparently is to get past pigeonholing. Being ‘upset’ always includes a whole range of things that are not going well, physically and emotionally. For better understanding and treatment, we really need to leave pigeonholing behind. I am very happy that, thanks to this grant, my fantastic team can make great strides in achieving this.

European Research Council

The European Research Council (ERC) is part of the European Commission. The ERC awards grants for pioneering research to a select number of excellent scientists. It is exceptional that Van Someren has now been awarded this most prestigious grant for the second time. His previously awarded project (2015) has yielded many innovative and applicable insights. Thanks to that project, we now have a better understanding of why insomnia can lead to depression and how we can prevent it.

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Portretfoto van Eus van Someren die poseert in het slaaplab.

Van Someren Group

Against the background of their 24-hour rhythm, driven by the circadian clock of the brain, sleep and wakefulness show a mutual dependency. The Sleep & Cognition group investigates how sleep affects brain function during subsequent wakefulness, and how experiences during wakefulness affect subsequent sleep. We aim firstly to elucidate factors that promote and disturb sleep at the systems level, notably insomnia, and secondly to investigate the brain mechanisms involved in the favorable and disruptive effects on cognition of, respectively, sleep and sleep disturbances. We think it’s important to translate fundamental insights into applications to improve sleep, vigilance and daytime function.

Human research tools include, in addition to the standard sleep-lab, brain imaging (high-density-EEG, MEG, fMRI on 1.5, 3 and soon 7 Tesla), transcranial magnetic stimulation (TMS), eye-tracking, computerized induction and assessment of task performance. The sleep-lab has a unique setup for comfortable skin temperature clamping in humans. An arsenal of ambulatory monitoring equipment is available. A web-based assessment tool for extensive insomnia and good sleep phenotyping has resulted in a growing database of, at present, 13000 people. The tool is available for other researchers that want to cooperate.

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