Support our work
Decorative header background

Adult neurogenesis, human after all (again)

Research group Salta
Publication year 2020
Published in Behavioural Brain Research
Authors Paul J Lucassen, C.P. Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic

In this perspective article, we reflect on the recent debate about the existence of human neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and functional relevance, of new neurons in the adult and aged human hippocampus. To explain the discrepancies between several prominently published human studies, we discuss critical methodological aspects and highlight the importance of optimal tissue preservation and processing for histological examination. We further discuss novel approaches, like single-cell/nucleus sequencing and magnetic resonance spectroscopy, that will help advance the study of human neurogenesis to its fullest potential – understanding its contribution to human hippocampal functions and related disorders like depression and dementia.

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work