Support our work
Decorative header background

Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder

Research group Willuhn
Publication year 2014
Published in Biological Psychiatry
Authors D. Denys, Martijn Figee, Pelle de Koning, Sanne Klaassen, Nienke C Vulink, Mariska H Mantione, Pepijn van den Munckhof, P Richard Schuurman, Guido van Wingen, Thérèse van Amelsvoort, Jan Booij,
The order of authors may deviate from the original publication due to temporary technical issues.

BACKGROUND: Obsessive-compulsive disorder is a chronic psychiatric disorder related to dysfunctional dopaminergic neurotransmission. Deep brain stimulation (DBS) targeted at the nucleus accumbens (NAc) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown.

METHODS: We measured the effects of NAc DBS in 15 patients on the dopamine D2/3 receptor availability in the striatum with [(123)I]iodobenzamide ([(123)I]IBZM) single photon emission computed tomography. We correlated changes in [(123)I]IBZM binding potential (BP) with plasma levels of homovanillic acid (HVA) and clinical symptoms.

RESULTS: Acute (1-hour) and chronic (1-year) DBS decreased striatal [(123)I]IBZM BP compared with the nonstimulated condition in the putamen. BP decreases were observed after 1 hour of stimulation, and chronic stimulation was related to concurrent HVA plasma elevations, implying DBS-induced dopamine release. BP decreases in the area directly surrounding the electrodes were significantly correlated with changes in clinical symptoms (45% symptom decrease).

CONCLUSIONS: NAc DBS induced striatal dopamine release, which was associated with increased HVA plasma levels and improved clinical symptoms, suggesting that DBS may compensate for a defective dopaminergic system.

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work