Support our work
Decorative header background

Dementia With Lewy Bodies

Publication year 2020
Published in Alzheimer Disease and Associated Disorders
Authors A.J.M. Rozemuller, Frank de Jong, Leonie J M Vergouw, Luca P Marler, Wilma D J van de Berg,
The order of authors may deviate from the original publication due to temporary technical issues.

Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled retrospectively from the Netherlands Brain Bank when they met the clinical criteria of probable DLB, but with a pathologic diagnosis other than DLB or Parkinson’s disease dementia. Twenty-two false-positive cases were selected. Alzheimer disease with or without copathology was the most common (64%) pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical clinical signs for DLB were present in almost half of the cases and could be a trigger to consider other diagnoses than DLB. Additional diagnostic examinations, feedback of pathologic diagnosis, and the creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases.

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work