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DNA methylation differences in cortical grey and white matter in schizophrenia

Publication year 2021
Published in Epigenomics
Authors E.M. Hol, Amber Berdenis van Berlekom, Nina Notman, Marjolein Am Sneeboer, Gijsje Jlj Snijders, Lotte C Houtepen, Danny M Nispeling, Yujie He, Stella Dracheva, René S Kahn, Lot D de Witte, Marco P M Boks,

Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.

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