Support our work
Decorative header background

Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coil

Research group Huitinga
Publication year 2018
Published in Frontiers in Cellular Neuroscience
Authors Inge C. M. Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Jeroen Melief, Mercedes Valls Seron, Judith H. M. P. Houben-Weerts, I. Huitinga, David J. van Westerloo, Tom van der Poll, Willem A. van Gool, Diederik van de Beek

Microglial activation after systemic infection has been suggested to
mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live bacteria and lipopolysaccharide (LPS). Here, we describe a mouse model of microglial activation after systemic challenge with live Escherichia coli (E. coli) and compare results with systemic challenge with LPS.

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work