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Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coil

Research group Huitinga
Publication year 2018
Published in Frontiers in Cellular Neuroscience
Authors I. Huitinga, Inge C. M. Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Jeroen Melief, Mercedes Valls Seron, Judith H. M. P. Houben-Weerts, David J. van Westerloo, Tom van der Poll, Willem A. van Gool, Diederik van de Beek,
The order of authors may deviate from the original publication due to temporary technical issues.

Microglial activation after systemic infection has been suggested to
mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live bacteria and lipopolysaccharide (LPS). Here, we describe a mouse model of microglial activation after systemic challenge with live Escherichia coli (E. coli) and compare results with systemic challenge with LPS.

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