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Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coil

Research group Huitinga
Publication year 2018
Published in Frontiers in Cellular Neuroscience
Authors Inge C. M. Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Jeroen Melief, Mercedes Valls Seron, Judith H. M. P. Houben-Weerts, I. Huitinga, David J. van Westerloo, Tom van der Poll, Willem A. van Gool, Diederik van de Beek
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Microglial activation after systemic infection has been suggested to
mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live bacteria and lipopolysaccharide (LPS). Here, we describe a mouse model of microglial activation after systemic challenge with live Escherichia coli (E. coli) and compare results with systemic challenge with LPS.

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