Support our work
Decorative header background

Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3

Research group De Zeeuw
Publication year 2017
Published in Neuron
Authors Cathrin Canto, H.W. Kessels, C.I. De Zeeuw, Nicolas Gutierrez-Castellanos, Carla M da Silva-Matos, Kuikui Zhou, Maria C Renner, Linda M C Koene, Ozgecan Ozyildirim, Rolf Sprengel,
The order of authors may deviate from the original publication due to temporary technical issues.

Accumulating evidence indicates that cerebellar long-term potentiation (LTP) is necessary for procedural learning. However, little is known about its underlying molecular mechanisms. Whereas AMPA receptor (AMPAR) subunit rules for synaptic plasticity have been extensively studied in relation to declarative learning, it is unclear whether these rules apply to cerebellum-dependent motor learning. Here we show that LTP at the parallel-fiber-to-Purkinje-cell synapse and adaptation of the vestibulo-ocular reflex depend not on GluA1- but on GluA3-containing AMPARs. In contrast to the classic form of LTP implicated in declarative memory formation, this form of LTP does not require GluA1-AMPAR trafficking but rather requires changes in open-channel probability of GluA3-AMPARs mediated by cAMP signaling and activation of the protein directly activated by cAMP (Epac). We conclude that vestibulo-cerebellar motor learning is the first form of memory acquisition shown to depend on GluA3-dependent synaptic potentiation by increasing single-channel conductance.

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work