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PRRT2-dependent dyskinesia

Research group De Zeeuw
Publication year 2018
Published in Cell Research
Authors Lieke Kros, C.I. De Zeeuw

In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.

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