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Sexual differentiation of the human brain: relevance for gender identity, transsexualism and sexual orientation.

Research group Swaab
Publication year 2004
Published in Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology
Authors D.F. Swaab,

Male sexual differentiation of the brain and behavior are thought, on the basis of experiments in rodents, to be caused by androgens, following conversion to estrogens. However, observations in human subjects with genetic and other disorders show that direct effects of testosterone on the developing fetal brain are of major importance for the development of male gender identity and male heterosexual orientation. Solid evidence for the importance of postnatal social factors is lacking. In the human brain, structural diferences have been described that seem to be related to gender identity and sexual orientation.

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