Key publications

Robke R, Sansi F, Arbab T, Tunez A, Moore M, Bartsch D, Schönig K, Willuhn I. Optogenetic Stimulation of Novel Tph2-Cre Rats Advances Insight into Serotonin’s Role in Locomotion, Reinforcement, and Compulsivity. J Neurosci. 2025 May 21;45(21):e1424242025. doi: 10.1523/JNEUROSCI.1424-24.2025.

van den Boom BJG, Elhazaz-Fernandez A, Rasmussen PA, van Beest EH, Parthasarathy A, Denys D, Willuhn I. Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model. Nat Commun. 2023 Sep 4;14(1):5385. doi: 10.1038/s41467-023-41026-x.

Goedhoop J, Arbab T, Willuhn I. Anticipation of Appetitive Operant Action Induces Sustained Dopamine Release in the Nucleus Accumbens. J Neurosci. 2023 May 24;43(21):3922-3932. doi: 10.1523/JNEUROSCI.1527-22.2023. Epub 2023 Apr 25.
PMID: 37185100

Goedhoop JN, van den Boom BJG, Robke R, Veen F, Fellinger L, van Elzelingen W, Arbab T, Willuhn I. Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error. Elife. 2022 Nov 11;11:e82711. doi: 10.7554/eLife.82711.

van Elzelingen, W., Goedhoop, J., Warnaar, P., Denys, D., Arbab, T., & Willuhn, I. A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli. Proceedings of the National Academy of Sciences (2022)

van Elzelingen, W., Warnaar, P., Matos, J., Bastet, W., Jonkman, R., Smulders, D., … & Willuhn, I. Striatal dopamine signals are region specific and temporally stable across action-sequence habit formation. Current Biology (2022)

de Groot A, van den Boom B, van Genderen RM, Coppens J, van Veldhuijzen J, Bos J, Hoedemaker H, Negrello M, Willuhn I, De Zeeuw CI, Hoogland TM. NINscope, a versatile miniscope for multi-region circuit investigations eLife (2020)

van den Boom BJG, Mooij AH, Misevičiūtėa I, Denys D, Willuhn. Behavioral flexibility in a mouse model for OCD: impaired Pavlovian reversal learning in SAPAP3 mutants Genes, Brain and Behavior (2019)

Pinhal C, van den Boom BJG, Santana-Kragelund F, Fellinger L, Bech P, Hamelink R, Feng G, Willuhn I, Feenstra MGP, Denys D. Differential effects of deep brain stimulation of the internal capsule and the striatum on excessive grooming in Sapap3 mutant mice Biol Psychiatry (2018)

Figee M, Pattij T, Willuhn I, Luigjes J, van den Brink W, Goudriaan A, Potenza MN, Robbins TW, Denys D. Compulsivity in obsessive-compulsive disorder and addictions European Neuropsychopharmacology (2016)