Support our work
Decorative header background

A unified 3D map of microscopic architecture and MRI of the human brain

Research group Swaab
Publication year 2022
Published in Science advances
Authors Anneke Alkemade, P.L. Bazin, R.A. Balesar, Kerrin Pine, Evgeniya Kirilina, Harald E Möller, Robert Trampel, Johan M Kros, Max C Keuken, Ronald L A W Bleys, D.F. Swaab, Andreas Herrler, Nikolaus Weiskopf, Birte Forstmann

We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D maps each integrate data from approximately 800 microscopy sections per brain, showing neuronal and glial cell bodies, nerve fibers, and interneuronal populations, as well as ultrahigh-field quantitative MRI, all coaligned at the 200-μm scale to the stacked blockface images obtained during sectioning. These unprecedented 3D multimodal datasets are shared without any restrictions and provide a unique resource for the joint study of cell and fiber architecture of the brain, detailed anatomical atlasing, or modeling of the microscopic underpinnings of MRI contrasts.

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work