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The functional microscopic neuroanatomy of the human subthalamic nucleus

Research group Swaab
Publication year 2019
Published in Brain Structure & Function
Authors Anneke Alkemade, R.A. Balesar, D.F. Swaab, Birte Forstmann, Gilles de Hollander, Steven Miletic, Max C Keuken, Onno de Boer,
The order of authors may deviate from the original publication due to temporary technical issues.

The subthalamic nucleus (STN) is successfully used as a surgical target for deep brain stimulation in the treatment of movement disorders. Interestingly, the internal structure of the STN is still incompletely understood. The objective of the present study was to investigate three-dimensional (3D) immunoreactivity patterns for 12 individual protein markers for GABA-ergic, serotonergic, dopaminergic as well as glutamatergic signaling. We analyzed the immunoreactivity using optical densities and created a 3D reconstruction of seven postmortem human STNs. Quantitative modeling of the reconstructed 3D immunoreactivity patterns revealed that the applied protein markers show a gradient distribution in the STN. These gradients were predominantly organized along the ventromedial to dorsolateral axis of the STN. The results are of particular interest in view of the theoretical underpinning for surgical targeting, which is based on a tripartite distribution of cognitive, limbic and motor function in the STN.

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