Support our work
Decorative header background

Parkinson’s disease

Problems with sleep and daytime vigilance are usually both present in the top three of complaints most affecting the quality of life in Parkinson’s disease. The monitoring of sleep-wake rhythms in field studies cannot validly be done using the regular actigraph, because high levels of activity can both mean unconstrained physical activity as well as debilitating tremor. We therefore developed and validated a dedicated actigraph that allows for unrestricted long-term simultaneous monitoring of both tremor and normal physical activity (Van Someren et al., 2006). Using this system, we demonstrated that the application of by repetitive transcranial magnetic stimulation (rTMS) over the parietal, but not over the motor cortex improved sleep considerably (Van Dijk et al., in revision). The finding supports the recent idea that local differences in cortical sleep pressure can be induced with local differences in neuronal activation during prior wakefulness. They also extend previous findings suggesting that higher order cortical areas have a leading role in the expression of sleep-related cortical activity – in contrast to the predominant primary to higher-order cortical area information stream typical of wakefulness.


At the moment, there are no vacancies within this group

Show all vacancies
Logo shape right


Have a question? Ask it directly to the Research topics

"*" indicates required fields


Donate to NiN

"*" indicates required fields

1Step 1: your donation
2Step 2: your details
Amount (most people donate 25 euros per quarter)*

Brain Friends make groundbreaking brain research possible

  • You support groundbreaking/ innovative brain research
  • You support the Dutch Brain Bank
  • Invitation to the Brain Friends Lecture
  • Exclusive friend activities
  • A look behind the scenes of the Netherlands Institute for Neuroscience
You can easily donate via

You can also transfer your contribution to NL76 INGB 0002 1673 78 in the name of ‘Stichting Vrienden van het Herseninstituut’

Support our work!

The Friends Foundation facilitates groundbreaking brain research. You can help us with that.

Support our work